Introduction: In this enlightening episode of the H.V.M.N. podcast, host Latt Mansor engages in a thought-provoking discussion with the esteemed Dr. Carolina Reis. Together, they delve into the fascinating topic of how skin inflammation can contribute to the development of various diseases. Join them as they explore the intricate relationship between skin health, aging, and overall well-being.

In their conversation, Latt and Dr. Reis highlight the connection between skin inflammation and systemic inflammatory responses that can manifest as diseases. They discuss how senescent cells, which are known to secrete inflammatory cytokines such as IL-8, IL-6, and TNF-alpha, can increase the risk of chronic diseases and mortality when present in elevated levels in the bloodstream.

Dr. Reis introduces a compelling ongoing study that examines the effects of topical treatments on cytokine levels. By collecting blood samples from participants and evaluating the impact of these treatments on reducing inflammatory cytokines, they aim to determine whether improving skin health and barrier function can effectively lower cytokine production.

The conversation delves deeper into the complex network of hormones, cytokines, and signaling molecules within the body. Latt and Dr. Reis discuss how imbalances or chronic fluctuations in these molecules can disrupt the body's compensatory mechanisms, leading to health issues. They emphasize that chronic inflammation, not limited to skin conditions like psoriasis or eczema, can have far-reaching effects, impacting the function of other organs as well.

Dr. Reis sheds light on the role of a peptide called OS1 in combating senescence, the process of cellular aging. The peptide helps decrease the release of senescence-associated secretory phenotype (SASP) from senescent cells. By reducing the inflammation caused by senescent cells, the peptide supports healthy cells and tissue, enabling better clearance of senescent cells and overall tissue recovery.

In conclusion, Latt and Dr. Reis highlight the significance of understanding the link between skin inflammation, aging, and overall health. By exploring these connections, researchers and healthcare professionals can develop interventions that not only address skin health but also potentially mitigate the development and progression of various diseases.

In this episode, you'll discover:

• Skin inflammation can contribute to the development of diseases and has systemic effects on the body.
• Senescent cells that secrete inflammatory cytokines increase the risk of chronic diseases and mortality.
• Research is being conducted to determine if improving skin health and barrier function can lower cytokine production and reduce inflammation.

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Transcription

Dr. Latt Mansor:

When you talk about inflammation in the skin, that leads to a systemic inflammatory response, hence manifesting a disease. Can you give us an example how that could occur and what kind of disease are you talking about?

Carolina Reis:

Yeah, so basically because senescent cells secretes several of those, you know, uh, kines such as I L eight, i L six, uh, TNF alpha, that's all related to chronic diseases, right? If you have in your blood, like elevated levels of those cytokines, you are more prone to chronic disease and even mortality. So we, we are running a very interesting study in which. We are collecting blood, uh, from the participants and then they start to using the topical products in their whole body, and then after three months, we are collecting blood again to evaluate if this topical treatment can actually reduce your levels of cytokines. Inflammatory cytokines just by treating your skin, by recovering, you know, the health and, you know, the, the, your skin barrier and how this could impact the, the cytokines production.

Latt Mansor:

Okay, well that, well, that explains a lot because, you know, um, as a system, our body as a system is a network of very varying, um, hormones and cytokines and signaling molecules. So when one goes wrong, most of the time, Another pathway would get upregulated or down-regulated to compensate, and that's where things go wrong. If you have a, an chronic elevation or chronic decrease of a certain, um, signaling molecules or uh, uh, inflammatory markers, then that's when things go, um, really wrong.

Carolina Reis:

And, and it's already known that, you know, for people that have more psoriasis and you know, like skin. Eczema, you already have like higher, you know, levels of inflammation coming from your skin. But the aging process itself can also, you know, create this inflammation. And that's what we wanna actually validate.

Latt Mansor:

So because aging affects everyone, not only people that have, you know, psoriasis or exam. And this is so true because people with psoriasis also often have problems with their joints. So not just their skin because of the chronic inflammation in the body. It's also affecting the function of other organs as well. So, um, okay. So now we know that, you know how skin health or aging of the skin relates so strongly with overall health. How does OS one as a peptide help with. The senescence, does it help with the inflammatory markers? Does it help with the clearing of the senescence cells? Does it help reversing the senescence? What does it do?

Carolina Reis:

Yeah. Awesome question. And actually we're about to publish our paper manuscript that actually. Explains this [00:03:00] really well. So if by the time that this podcast release, we'll definitely, you know, attach the, the manuscript there. Uh, but basically the peptide helps like decreasing the release of, you know, sas that's like the. Senescence associated a secretary phenotype from senescent cells. So this, the, the signaling molecules that are coming from senescent cells, the peptide block, that secretion, and actually this is the main harm that, you know, senescence cells cause is like their secretion will induce other cells to age fast and to become senescent. So we have several experiments showing that.

If we have a senescent cells and, and we incubate with the peptide and we get that condition media basically, you know, the media that the cell is, uh, It is in contact with, and we put in contact with healthy cells. We have like less senescent cells formed in the healthy cells because the peptide, you know, helped decrease in the amount of inflammation, uh, secreted by the senescent cells. And the way that it does this, That is by, uh, for, you know, there are several mechanisms, I would say signaling pathways that are activated, but one of them is like DNA repair pathways.

Another one is a protein. It's a complex of a protein called PPP two A. That's. Stabilize, like, uh, your, the genome as a whole. So with that you have like less senescent cells and your tissue gets less overwhelmed and then your tissue can do its work better in terms of clear clearing up this. You know, senescent cells that are still around there. So our peptide itself does not like kill the senescent cells, but by reducing the amount of senescent cells that is being formed, your tissue can actually do its job and, and clear up the senescent cells and recover that, you know, health state.

Latt Mansor:

So let me recap. So first it reduces the signaling molecules from senescent cells itself, and by doing that, you are also reducing the occurrence, uh, the emergence of new senescent cells.

 

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